80,000 Hours (80K) is an organization that offers free, one-on-one career advice to individuals seeking to use their careers to do the most good in the world. 80K also publishes general research on the social impact of careers to its website.

Against Malaria Foundation (AMF) is a non-profit that funds the distribution of long-lasting insecticidal nets (LLIN) to areas with high incidence of malaria, mostly in Africa. GiveWell has recommended AMF as a top charity several times. As of 2017, GiveWell estimated that it costs AMF about $4.22 to distribute one LLIN and $3,000 per equivalent under-5 year old life saved.

Animal Charity Evaluators investigates the most effective ways of reducing non-human animal suffering. Since there are many non-human animals living in extremely painful conditions on factory farms, animal suffering could be a very highly effective altruistic cause.

Animal Equality advocates for animals in the U.S., Europe, Latin America, India, and China. They conduct investigations, engage in grassroots advocacy, run corporate and legislative campaigns, and make significant efforts to research the impact of their programs.

Center for Applied Rationality runs 4 day workshops on, no surprises here, rationality. They often give significant discounts to effective altruists, and a lot of people report benefiting from their workshops.

Centre for Effective Altruism (CEA) is a coalition of projects related to EA. Giving What We Can and 80,000 Hours are both part of CEA. They also run the Global Priorities Project and other special projects and raise public awareness of EA.

Charity Science Foundation is an umbrella organization with the ultimate goal of helping relieve as much suffering as possible.

Effective Altruism Foundation (EAF, German: Stiftung für Effektiven Altruismus) is an independent, non-profit think tank and project incubator looking for the best ways to help as many individuals as possible.

Future of Humanity Institute (FHI) is a research center at Oxford that is a leading producer of research on existential risk. FHI’s main areas of research are global catastrophic risk, applied epistemology, human enhancement, and future technologies.

GiveDirectly transfers cash to households in developing countries via mobile phone-linked payment services. It targets extremely low-income households.

Giving What We Can is an international society dedicated to eradicating extreme poverty. GWWC recommends cost-effective charities and encourages individuals to sign its pledge, which represents a commitment to donate a fraction of one’s income to effective charities.

GiveWell is a non-profit that evaluates charities in order to find outstanding giving opportunities. In particular, GiveWell seesk out charities who provide strong evidence of impact-per-dollar and room for more funding, and who can demonstrate trustworthiness and transparency. GiveWell recommends just a few charities at a time and these recommendations inform the donations of many effective altruists.

Machine Intelligence Research Institute (MIRI) is an non-profit whose mission is to “ensure that the creation of smarter-than-human intelligence has a positive impact.” MIRI’s main activity is to conduct research on a topics such as: How can a machine reason coherently about its own behavior? What is a better formalization for decision-making under uncertainty? How can we specify an AI’s goals to ensure that it matches our intentions, even as the AI modifies itself? What AI-related interventions are the most beneficial?

Open Philanthropy Project identifies outstanding giving opportunities, makes grants, follows the results, and publishes their findings. Their main funders are Cari Tuna and Dustin Moskovitz, a co-founder of Facebook and Asana.

OpenAI is a non-profit AI research company, discovering and enacting the path to safe artificial general intelligence.

Raising for Effective Giving (REG), a project from EAF, encourages touring poker players to donate 2% of their winnings to effective charity (which sometimes totals tens of millions).

Rethink Charity, formerly known as .impact, runs a lineup of EA initiatives that facilitate interpersonal engagement from the bottom up. Initiatives include LEAN (the Local Effective Altruism Network), the EA Hub, Students for High Impact Charity (SHIC), and RC Forward (Canada’s first cause-neutral donation routing fund for high-impact charities).

Schistosomiasis Control Initiative (SCI) is a non-profit that works with local Ministries of Health across sub-Saharan Africa to treat children and at-risk adults for schistosomiasis and other parasitic worms. GiveWell has recommended SCI as a top charity, and in 2013, estimated that it costs $0.80 to deworm one child, with SCI paying about 70% of these costs (see “leveraging donations”).

Sentience Politics is an effectiveness-focused anti-speciesist political think tank with the goal of reducing the suffering of all sentient beings. In spring 2018 they launched a national ballot initiative that calls for the abolition of factory farming in Switzerland.

The Good Food Institute works in an underutilized but critically important area by promoting and aiding the development of competitive alternatives to animal-based meat, dairy, and eggs.

The Humane League has built an especially effective corporate outreach department that has achieved substantial progress for millions of animals over the past year, often through collaborative campaigns with other advocacy groups.

The Life You Can Save is a non-profit founded by philosopher Peter Singer. It promotes effective giving – with a focus on reducing poverty and economic inequality – through public outreach. TLYCS seeks to create local groups of informed givers and a global online community, and encourages individuals to sign its charitable-donation pledge.

Several organizations are focused on existential risk and the far future of humanity. The Future of Humanity Institute (FHI), the Centre for the Study of Existential Risk (CSER), and the Future of Life Institute (FLI) use the tools of mathematics, philosophy, and science to research big-picture questions about the future of humankind.